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AGILENT HPLC

AGILENT HPLC

AGILENT HPLC

AUTOSAMPLER
QUATERNARY PUMP
COLUMN OVEN
VWD DETECTOR
DAD AND MWD

Type Specification
GLP features Early maintenance feedback (EMF), electronic records of maintenance and errors
Communications Controller-area network (CAN). GPIB (IEEE-448), RS232C, APG-remote standard, optional four external contact closures and BCD vial number output
Safety features Leak detection and safe leak handling, low voltages in maintenance areas, error detection and display
Injection range 0.1 – 100 μl in 0.1 μl increments Up to 1500 μl with multiple draw (hardware modification required)
Replicate injections 1 – 99 from one vial
Precision Typically < 0.5 % RSD of peak areas from 5 – 100 μl, Typically < 1 % RSD of peak areas from 1 – 5 μl
Minimum sample volume 1 μl from 5 μl sample in 100 μl microvial, or 1 μl from 10 μl sample in 300 μl microvial
Carryover Typically < 0.1 %, < 0.05 % with external needle cleaning
Sample viscosity range 0.2 – 50 cp
Replicate injections per vial 1 – 99
Sample capacity 100 × 2-ml vials in 1 tray
40 × 2-ml vials in ½ tray
15 × 6-ml vials in ½ tray (Agilent vials only)
Injection cycle time Typically 50 s depending on draw speed and injection volume

Type Specification

Hydraulic system

Dual plunger in series pump with proprietary servo-controlled variable stroke drive, floating plungers and active inlet valve

Setable flow range

0.001 – 10 ml/min, in 0.001 ml/min increments

Flow range

0.2 – 10.0 ml/min

Flow precision

< 0.3 % RSD (typically 0.15 %), based on retention time, at 1 ml/min

Pressure

Operating range 0 – 40 MPa (0 – 400 bar, 0 – 5880 psi) up to 5 ml/min Operating range 0 – 20 MPa (0 – 200 bar, 0 – 2950 psi) up to 10 ml/min

Pressure pulsation

< 2 %amplitude (typically < 1 %), at 1 ml/min isopropanol,
at all pressures > 1 MPa (10bar)

Compressibility compensation

User-selectable, based on mobile phase compressibility

Recommended pH

1.0 – 12.5, solvents with pH > 2.3 should not contain acids which attack

Range

stainless steel

Gradient formation

Low pressure quaternary mixing/gradient capability using proprietary
high-speed proportioning valve
Delay volume 800 – 1100 μl, dependent on back pressure

Composition Range

0 – 95 % or 5 – 100 %, user selectable

Composition Precision

< 0.2 % RSD, at 0.2 and 1 ml/min

Control and data evaluation

Agilent ChemStation for LC

Analog output

For pressure monitoring, 2 mV/bar, one output

Communications

Controller-area network (CAN), GPIB, RS-232C, APG Remote: ready, start, stop and shut-down signals, LAN optional


Type Specification

Temperature range

10 degrees below ambient to 80 °C

Temperature stability

± 0.15 °C

Temperature accuracy

± 0.8 °C
± 0.5 °C With calibration

Column capacity

Three 30 cm

Warm-up/cool-down

5 minutes from ambient to 40 °C

Time

10 minutes from 40 – 20 °C

Dead volume

3 μl left heat exchanger

Dimensions

6 μl right heat exchanger
140 × 410 × 435 mm

(h × w × d)

(5.5 × 16 × 17 inches)

Weight   

10.2 kg (22.5 lbs)

Communications

Controller-area network (CAN), GPIB,
RS-232C, APG Remote: ready, start, stop
and shut-down signals, LAN optional


Type Specification

Detection type

Double-beam photometer

Light source

Deuterium lamp

Wavelength range

190–600 nm

Short term noise

± 0.75 × 10-5 AU at 254 nm

(ASTM)

Drift

3 × 10-4 AU/hr at 254

Linearity

> 2 AU (5%) upper limit

Wavelength accuracy

± 1 nm Self-calibration with deuterium lines,

 

verification with holmium oxide filter

Band width

6.5 nm typical

Flow cells

Standard: 14-μl volume, 10-mm

 

cell path length and 40 bar

 

(588 psi) pressure maximum

 

High pressure: 14-μl volume,

 

10-mm cell path length and

 

400 bar (5880 psi) pressure

 

maximum

 

Micro: 1-μl volume, 5-mm cell

 

path length and 40 bar (588 psi)

 

pressure maximum

 

Semimicro: 5-μl volume, 6-mm

 

cell path length and 40 bar

 

(588 psi) pressure maximum

Control and data

Agilent ChemStation for LC

evaluation

Analog outputs

Recorder/integrator: 100 mV or

 

1 V, output range 0.001 – 2 AU,

 

one output

Communications

Controller-area network (CAN),

 

GPIB, RS-232C, APG Remote:

 

ready, start, stop and

 

shut-down signals, LAN

 

optional


Type Specification

Detection type

1024-element photodiode array

Light source

Deuterium and tungsten lamps

Wavelength range

190 – 950 nm

Short term noise (ASTM)

± 1 × 10-5 AU at 254 and 750 nm

 

Single and Multi-Wavelength Drift

2 × 10-3 AU/hr at 254 nm

 

 

Linear absorbance range

> 2 AU (upper limit)

 

Wavelength accuracy

± 1 nm Self-calibration with deuterium lines,

 

verification with holmium oxide filter

Wavelength bunching

1 – 400 nm Programmable in steps of 1 nm

Slit width

1, 2, 4 , 8, 16 nm Programmable slit

Diode width

< 1 nm

Flow cells

Standard: 13 μl volume, 10 mm cell path

 

length and 120 bar (1760 psi)

 

pressure maximum

 

Semi-Micro: 5 μl volume, 6 mm cell

 

path length and 120 bar (1760 psi)

 

pressure maximum

 

High pressure: 1.7 μl volume, 6 mm cell

 

path length and 400 bar (5880 psi)

 

pressure maximum

 

500 nano: 0.5 μl volume, 10 mm cell

 

path length and 50 bar (725 psi)

 

pressure maximum

Control and data evaluation

Agilent ChemStation for LC

Analog outputs

Recorder/integrator: 100 mV or 1 V,

 

output range 0.001 – 2 AU, two outputs

Communications

Controller-area network (CAN), GPIB,

 

RS-232C, APG Remote: ready, start,

 

stop and shut-down signals, LAN optional